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High-intensity focused ultrasound tumor ablation: Review of ten years of clinical experience

Lian ZHANG, Zhi-Biao WANG

《医学前沿（英文）》 2010年 第4卷 第3期   页码 294-302 doi: 10.1007/s11684-010-0092-8

摘要： High-intensity focused ultrasound (HIFU) is a technique to destroy tissue at depth within the body, selectively and without harming overlying and adjacent structures within the path of the beam because the ultrasonic intensity at the beam focus is much higher than that outside of the focus. Diagnostic ultrasound is the first imaging modality used for guiding HIFU ablation. In 1997, a patient with osteosarcoma was first successfully treated with ultrasound imaging-guided HIFU in Chongqing, China. Over the last decade, thousands of patients with uterine fibroids, liver cancer, breast cancer, pancreatic cancer, bone tumors, and renal cancer have been treated with ultrasound imaging-guided HIFU. Based on several research groups’ reports, as well as our ten-year clinical experience, we conclude that this technique is safe and effective in treating human solid tumors. HIFU is a promising technique. Most importantly, HIFU offers patients another alternative when those patients have no other treatment available.

关键词： high-intensity focused ultrasound (HIFU)     ultrasound imaging-guided HIFU (USgHIFU)     magnetic resonance imaging-guided HIFU (MRgHIFU)    

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Discovery of the mechanisms of acupuncture in the treatment of migraine based on functional magneticresonance imaging and omics

《医学前沿（英文）》   页码 993-1005 doi: 10.1007/s11684-023-0989-7

摘要： Migraine is one of the most prevalent and disabling neurological disease, but the current pharmacotherapies show limited efficacy and often accompanied by adverse effects. Acupuncture is a promising complementary therapy, but further clinical evidence is needed. The influence of acupuncture on migraine is not an immediate effect, and its mechanism remains unclear. This study aims to provide further clinical evidence for the anti-migraine effects of acupuncture and explore the mechanism involved. A randomized controlled trial was performed among 10 normal controls and 38 migraineurs. The migraineurs were divided into blank control, sham acupuncture, and acupuncture groups. Patients were subjected to two courses of treatment, and each treatment lasted for 5 days, with an interval of 1 day between the two courses. The effectiveness of treatment was evaluated using pain questionnaire. The functional magnetic resonance imaging (fMRI) data were analyzed for investigating brain changes induced by treatments. Blood plasma was collected for metabolomics and proteomics studies. Correlation and mediation analyses were performed to investigate the interaction between clinical, fMRI and omics changes. Results showed that acupuncture effectively relieved migraine symptoms in a way different from sham acupuncture in terms of curative effect, affected brain regions, and signaling pathways. The anti-migraine mechanism involves a complex network related to the regulation of the response to hypoxic stress, reversal of brain energy imbalance, and regulation of inflammation. The brain regions of migraineurs affected by acupuncture include the lingual gyrus, default mode network, and cerebellum. The effect of acupuncture on patients’ metabolites/proteins may precede that of the brain.

关键词： acupuncture     migraine     fMRI     metabolome     proteome    

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基于超声引导的高精度机器人辅助HIFU 乳腺癌治疗系统 Article

Tianhan Tang,Takashi Azuma,Toshihide Iwahashi,Hideki Takeuchi,Etsuko Kobayashi,Ichiro Sakuma

《工程（英文）》 2018年 第4卷 第5期   页码 702-713 doi: 10.1016/j.eng.2018.07.008

摘要： 高强度聚焦超声（波）（HIFU）是一种很有前景的非介入式治疗方法。为了提高HIFU 治疗的精确度和降低治疗成本，开发了一套基于超声引导（US）的五自由度辅助HIFU 系统。搭建了一套功能齐全的样机，它可以轻松地实现三维超声图像重建、目标分割、治疗路径生成和HIFU 自动照射等功能。利用线模型实现点定位，并且在异构组织模型上对凝固区域进行评估。在超声引导下，HIFU 治疗区域的中心偏离目标治疗区域中心不到2 mm。规划治疗区域周围出现的超调值远低于在临床使用的允许值。对于乳腺癌的治疗，本系统有足够的准确性。

关键词： HIFU     乳腺癌     超声引导     医疗机器人     准确性评估    

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Machine learning for detecting mesial temporal lobe epilepsy by structural and functional neuroimaging

Baiwan Zhou, Dongmei An, Fenglai Xiao, Running Niu, Wenbin Li, Wei Li, Xin Tong, Graham J Kemp, Dong Zhou, Qiyong Gong, Du Lei

《医学前沿（英文）》 2020年 第14卷 第5期   页码 630-641 doi: 10.1007/s11684-019-0718-4

摘要： Mesial temporal lobe epilepsy (mTLE), the most common type of focal epilepsy, is associated with functional and structural brain alterations. Machine learning (ML) techniques have been successfully used in discriminating mTLE from healthy controls. However, either functional or structural neuroimaging data are mostly used separately as input, and the opportunity to combine both has not been exploited yet. We conducted a multimodal ML study based on functional and structural neuroimaging measures. We enrolled 37 patients with left mTLE, 37 patients with right mTLE, and 74 healthy controls and trained a support vector ML model to distinguish them by using each measure and the combinations of the measures. For each single measure, we obtained a mean accuracy of 74% and 69% for discriminating left mTLE and right mTLE from controls, respectively, and 64% when all patients were combined. We achieved an accuracy of 78% by integrating functional data and 79% by integrating structural data for left mTLE, and the highest accuracy of 84% was obtained when all functional and structural measures were combined. These findings suggest that combining multimodal measures within a single model is a promising direction for improving the classification of individual patients with mTLE.

关键词： mesial temporal lobe epilepsy     functional magnetic resonance imaging     structural magnetic resonance imaging     machine learning     support vector machine    

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全氟化碳乳剂19F磁共振成像的最新进展 Review

Anne H. Schmieder,Shelton D. Caruthers,Jochen Keupp,Samuel A. Wickline,Gregory M. Lanza

《工程（英文）》 2015年 第1卷 第4期   页码 475-489 doi: 10.15302/J-ENG-2015103

摘要：

19F磁共振成像(MRI) 的研究可追溯到30多年前。在这30多年间，氢原子核(1H)成像技术迅速发展，并在全球得到广泛应用，使得磁共振成像成为生物医学诊断成像技术中不可缺少的支柱。多年来，由于各种原因，对19F成像技术的研究进展缓慢。但是在过去的十年间，尤其是最近几年，19F成像的研究和临床相关性呈爆发式发展。部分原因归结为MRI仪器、19F/1H线圈设计以及临床前和临床核磁共振仪的超高速脉冲序列的发展。这些成就再加上对解剖生理学分子成像技术的兴趣以及一批创新造影剂的出现使19F的概念进入了早期的临床评估中。本篇综述重点探讨以液态全氟化碳化合物为基础的造影剂，并试图呈现这段丰富的研究和发展历史。

关键词： 氟     磁共振成像(MRI)     双调线圈     全氟化碳     血管生成术     细胞标记    

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参与中文配对词语联想学习记忆的脑区和神经机制——脑功能磁共振的研究

郑金龙,舒斯云,刘颂豪,郭周义,吴永明,包新民, 张增强,金梅,马翰章

《中国工程科学》 2008年 第10卷 第5期   页码 38-45

摘要：

通过脑功能磁共振技术，研究健康人参与语言的词语配对联想学习记忆任务的脑区和神经机制。对16名右利手健康志愿者进行一项词语配对联想学习记忆任务作业的同时，进行脑功能磁共振扫描。实验采用组块设计，实验任务（包括记忆编码相和记忆提取相）与对照任务（共两个相）交替进行；数据采用SPM99软件进行数据分析和脑功能区定位。结果表明：左侧额叶，特别是左侧额叶的额中下回和枕叶的18，19区在词语联想学习记忆的编码阶段中起重要作用；而左侧顶上小叶、缘上回和角回则在进行记忆提取阶段起重要作用；左侧纹状体边缘区参与了人脑词语联想学习记忆作业的编码阶段。揭示了人大脑完成语言联想学习记忆任务时，除额、顶、枕和颞叶的皮层结构参与外，还新发现有皮层下结构如纹状体参与了词语联想学习记忆。在配对词语的编码和提取阶段，激活的脑区有所变化，显示了这两个语言阶段的神经活动变化机制。

关键词： 人脑功能磁共振     配对词语     语言     联想学习记忆     皮层和皮层下结构    

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基于双向深度生成模型和功能磁共振成像数据的大脑编码和解码 Review

杜长德, 李劲鹏, 黄利皆, 何晖光

《工程（英文）》 2019年 第5卷 第5期   页码 948-953 doi: 10.1016/j.eng.2019.03.010

摘要：

通过功能磁共振成像（fMRI）进行大脑编码和解码是视觉神经科学的两个重要方面。尽管以前的研究人员在大脑编码和解码模型方面取得了显著进步，但是现有方法仍需要使用先进的机器学习技术进行改进。例如，传统方法通常会分别构建编码和解码模型，并且容易对小型数据集过度拟合。实际上，有效地统一编码和解码过程可以进行更准确的预测。在本文中，我们首先回顾了现有的编码和解码方法，并讨论了“双向”建模策略的潜在优势。接下来，在体系结构和计算规则方面，我们证明了深度神经网络和人类视觉通路之间存在的对应关系。此外，深度生成模型[如变分自编码器（VAE）和生成对抗网络（GAN）]在大脑编码和解码研究中产生了可喜的成果。最后，我们提出了最初为机器翻译任务设计的对偶学习方法，该方法通过利用大规模未配对数据提高了编码和解码模型的效果。

关键词： 大脑编码和解码     功能磁共振成像     深度神经网络     深度生成模型     双重学习    

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Metabolomics in human type 2 diabetes research

null

《医学前沿（英文）》 2013年 第7卷 第1期   页码 4-13 doi: 10.1007/s11684-013-0248-4

摘要：

The high prevalence of diabetes and diabetic complications has caused a huge burden on the modern society. Although scientific advances have led to effective strategies for preventing and treating diabetes over the past several decades, little progress has been made toward curing the disease or even getting it under control, from a public health and overall societal standpoint. There is still a lack of reliable biomarkers indicative of metabolic alterations associated with diabetes and different drug responses, highlighting the need for the development of early diagnostic and prognostic markers for diabetes and diabetic complications. The emergence of metabolomics has allowed researchers to systemically measure the small molecule metabolites, which are sensitive to the changes of both environmental and genetic factors and therefore, could be regarded as the link between genotypes and phenotypes. During the last decade, the progression made in metabolomics has provided insightful information on disease development and disease onset prediction. Recent studies using metabolomics approach coupled with statistical tools to predict incident diabetes revealed a number of metabolites that are significantly altered, including branched-chain and aromatic amino acids, such as isoleucine, leucine, valine, tyrosine and phenylalanine, as diagnostic or highly-significant predictors of future diabetes. This review summarizes the current findings of metabolomic studies in human investigations with the most common form of diabetes, type 2 diabetes.

关键词： metabolomics     type 2 diabetes     metabolic pathway     mass spectrometry     nuclear magnetic resonance (NMR)    

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Copolymerization of 1-butene and 1-hexene with supported titanium catalyst

ZHAO Yongxian, SHAO Huafeng, WANG Bo, YAO Wei, HUANG Baochen

《化学科学与工程前沿（英文）》 2007年 第1卷 第3期   页码 304-309 doi: 10.1007/s11705-007-0056-y

摘要： With TiCl/MgCl (Ti) and Al(-Bu) (Al) as catalysts, the thermoplastic copolymer of 1-butene(Bt) and 1-hexene(He) was synthesized successfully. The effects of Bt/He, Ti/(He+Bt), Al/Ti, temperature and reaction time on conversion, catalyst efficiency(CE), intrinsic viscosity([η]) and insoluble content were studied. The copolymer was analyzed with Fourier transform-infrared (FTIR) and nuclear magnetic resonance (H-NMR). Results showed that the optimal polymerization conditions were: He/Bt = 0.25, temperature 40ºC–50ºC, Al/Ti = 400–500, Ti/(Bt+He) = 3×10-4*times;10, time 4 h. Intrinsic viscosity was found to increase with increasing Ti/(Bt+He) and decreasing Al/Ti and polymerization temperature. When the molar content of He, Al/Ti and polymerization temperature increased, the insoluble content in CHCl of copolymers decreased. When Ti/(Bt+He) and reaction time increased, the insoluble content in CHCl of copolymers also increased. The crystallization and stereoregularity of poly(1-butene) decreased with the addition of He.

关键词： reaction     conversion     temperature     polymerization temperature     magnetic resonance    

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肿瘤光学分子影像前沿技术：追求更精准和更灵敏 Review

王坤,迟崇巍,胡振华,刘沐寒,惠辉,尚文婷,彭冬,张爽,叶津佐,刘海哮,田捷

《工程（英文）》 2015年 第1卷 第3期   页码 309-323 doi: 10.15302/J-ENG-2015082

摘要：

以新发展的光学多模成像、契伦科夫荧光成像和光学影像手术导航技术为代表的光学分子影像前沿技术，开辟了肿瘤研究、临床转化和医疗实践的新前沿领域。相对于传统成像技术，新技术在活体肿瘤成像上可以提供前所未有的灵敏度和精准度。活体肿瘤细胞和分子行为与事件的可视化正在系统地促进人们对肿瘤的深度理解。这些成像技术的新进展正被快速应用于肿瘤诊疗，如对不同肿瘤之间分子异质性信息的动态和量化获取， 以及通过实时成像辅助实现更有效的治疗性干预。在分子影像的时代中，光学技术为促进高灵敏度肿瘤诊断和个体化治疗的发展带来了巨大的希望，而这些正是精准医学的终极目标之一。

关键词： 光学分子影像     多模分子成像     光学多模断层成像     契伦科夫荧光成像     光学影像手术导航    

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Multi-scale UDCT dictionary learning based highly undersampled MR image reconstruction using patch-based constraint splitting augmented Lagrangian shrinkage algorithm

Min YUAN,Bing-xin YANG,Yi-de MA,Jiu-wen ZHANG,Fu-xiang LU,Tong-feng ZHANG

《信息与电子工程前沿（英文）》 2015年 第16卷 第12期   页码 1069-1087 doi: 10.1631/FITEE.1400423

摘要： Recently, dictionary learning (DL) based methods have been introduced to compressed sensing magnetic resonance imaging (CS-MRI), which outperforms pre-defined analytic sparse priors. However, single-scale trained dictionary directly from image patches is incapable of representing image features from multi-scale, multi-directional perspective, which influences the reconstruction performance. In this paper, incorporating the superior multi-scale properties of uniform discrete curvelet transform (UDCT) with the data matching adaptability of trained dictionaries, we propose a flexible sparsity framework to allow sparser representation and prominent hierarchical essential features capture for magnetic resonance (MR) images. Multi-scale decomposition is implemented by using UDCT due to its prominent properties of lower redundancy ratio, hierarchical data structure, and ease of implementation. Each sub-dictionary of different sub-bands is trained independently to form the multi-scale dictionaries. Corresponding to this brand-new sparsity model, we modify the constraint splitting augmented Lagrangian shrinkage algorithm (C-SALSA) as patch-based C-SALSA (PB C-SALSA) to solve the constraint optimization problem of regularized image reconstruction. Experimental results demonstrate that the trained sub-dictionaries at different scales, enforcing sparsity at multiple scales, can then be efficiently used for MRI reconstruction to obtain satisfactory results with further reduced undersampling rate. Multi-scale UDCT dictionaries potentially outperform both single-scale trained dictionaries and multi-scale analytic transforms. Our proposed sparsity model achieves sparser representation for reconstructed data, which results in fast convergence of reconstruction exploiting PB C-SALSA. Simulation results demonstrate that the proposed method outperforms conventional CS-MRI methods in maintaining intrinsic properties, eliminating aliasing, reducing unexpected artifacts, and removing noise. It can achieve comparable performance of reconstruction with the state-of-the-art methods even under substantially high undersampling factors.

关键词： Compressed sensing (CS)     Magnetic resonance imaging (MRI)     Uniform discrete curvelet transform (UDCT)     Multi-scale dictionary learning (MSDL)     Patch-based constraint splitting augmented Lagrangian shrinkage algorithm (PB C-SALSA)    

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Time reversal method for guided wave inspection in pipes

DENG Fei, WU Bin, HE Cunfu

《机械工程前沿（英文）》 2008年 第3卷 第3期   页码 251-260 doi: 10.1007/s11465-008-0050-1

摘要： The application of the time reversal method in pipe-like structures based on finite element method (FEM) is investigated. A steel pipe model measuring 70 mm × 3.5 mm is used to analyze the reflection coefficient of the (0,2) mode with the time reversal process. Simulation results show that the time reversal array method is beneficial to the improvement of the signal-to-noise ratio of a guided wave inspection system. As the intercepting window is widened, more energy is included in re-emitted signals, which leads to a large reflection coefficient of the (0,2) mode. In parallel, a circumferential locating method based on the time reversal method is described. The time reversal process used for guided wave inspection leads to the temporal and spatial focusing. When the time reversal signals are re-emitted, the angular profile obtained at the axial location of the defect can be used to determine the circumferential location of the defect. Except for a pipe with one defect, the circumferential locating method has been verified on another pipe model with two defects. Meanwhile, the elements number of the time reversal array has been discussed for enhancing the discrimination of the defect circumferential location.

关键词： reversal process     beneficial     circumferential location     energy     number    

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Ultrasound-guided prostate percutaneous intervention robot system and calibration by informative particle

《机械工程前沿（英文）》 2022年 第17卷 第1期   页码 3-3 doi: 10.1007/s11465-021-0659-x

摘要： Applying a robot system in ultrasound-guided percutaneous intervention is an effective approach for prostate cancer diagnosis and treatment. The limited space for robot manipulation restricts structure volume and motion. In this paper, an 8-degree-of-freedom robot system is proposed for ultrasound probe manipulation, needle positioning, and needle insertion. A novel parallel structure is employed in the robot system for space saving, structural rigidity, and collision avoidance. The particle swarm optimization method based on informative value is proposed for kinematic parameter identification to calibrate the parallel structure accurately. The method identifies parameters in the modified kinematic model stepwise according to parameter discernibility. Verification experiments prove that the robot system can realize motions needed in targeting. By applying the calibration method, a reasonable, reliable forward kinematic model is built, and the average errors can be limited to 0.963 and 1.846 mm for insertion point and target point, respectively.

关键词： ultrasound image guidance     prostate percutaneous intervention     parallel robot     kinematics identification     particle swarm optimization     informative value    

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Modeling and analysis of magnetic dipoles in weak magnetic field

WANG Zhaoxia, ZHANG Weimin, LIU Hongguang

《机械工程前沿（英文）》 2008年 第3卷 第2期   页码 222-225 doi: 10.1007/s11465-008-0028-z

摘要： The magnetic leakage field distribution resulting from linear defects of a tube sample in the geomagnetic field is modeled according to the magnetic dipole theory. The formula to compute the normal component of the weak magnetic field is deduced based on the spatial distribution of the magnetic dipole. The shape and characteristics of the zero line (an important criterion for magnetic memory testing) of the normal field is analyzed under different longitudinal magnetizations. Results show that the characteristics of the zero line should be considered when the metal magnetic memory testing method is used to find and locate the defect.

关键词： geomagnetic     theory     important criterion     magnetic leakage     normal component    

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Multi-harmonic forced vibration and resonance of simple beams to moving vehicles

《结构与土木工程前沿（英文）》   页码 981-993 doi: 10.1007/s11709-023-0979-5

摘要： This study modeled the moving-vehicle-induced forcing excitation on a single-span prismatic bridge as a multiple frequency-multiplication harmonic load on the modal coordinates of a linear elastic simple Euler–Bernoulli beam, and investigated the forced modal oscillation and resonance behavior of this type of dynamic system. The forced modal responses consist of multiple frequency-multiplication steady-state harmonics and one damped mono-frequency complementary harmonic. The analysis revealed that a moving load induces high-harmonic forced resonance amplification when the moving speed is low. To verify the occurrence of high-harmonic forced resonance, numerical tests were conducted on single-span simple beams based on structural modeling using the finite element method (FEM) and a moving sprung-mass oscillator vehicle model. The forced resonance amplification characteristics of the fundamental mode for beam response estimation are presented with consideration to different end restraint conditions. The results reveal that the high-harmonic forced resonance may be significant for the investigated beams subjected to vehicle loads moving at specific low speeds. For the investigated single-span simple beams, the moving vehicle carriage heaving oscillation modulates the beam modal frequency, but does not induce notable variation of the modal oscillation harmonic structure for the cases that vehicle of small mass moves in low speed.

关键词： forced vibration     linear Euler beam     moving load     harmonic structure     frequency modulation     end restraints    

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标题 作者 时间 类型 操作

High-intensity focused ultrasound tumor ablation: Review of ten years of clinical experience

Lian ZHANG, Zhi-Biao WANG

期刊论文

Discovery of the mechanisms of acupuncture in the treatment of migraine based on functional magneticresonance imaging and omics

期刊论文

基于超声引导的高精度机器人辅助HIFU 乳腺癌治疗系统

Tianhan Tang,Takashi Azuma,Toshihide Iwahashi,Hideki Takeuchi,Etsuko Kobayashi,Ichiro Sakuma

期刊论文

Machine learning for detecting mesial temporal lobe epilepsy by structural and functional neuroimaging

Baiwan Zhou, Dongmei An, Fenglai Xiao, Running Niu, Wenbin Li, Wei Li, Xin Tong, Graham J Kemp, Dong Zhou, Qiyong Gong, Du Lei

期刊论文

全氟化碳乳剂19F磁共振成像的最新进展

Anne H. Schmieder,Shelton D. Caruthers,Jochen Keupp,Samuel A. Wickline,Gregory M. Lanza

期刊论文

参与中文配对词语联想学习记忆的脑区和神经机制——脑功能磁共振的研究

郑金龙,舒斯云,刘颂豪,郭周义,吴永明,包新民, 张增强,金梅,马翰章

期刊论文

基于双向深度生成模型和功能磁共振成像数据的大脑编码和解码

杜长德, 李劲鹏, 黄利皆, 何晖光

期刊论文

Metabolomics in human type 2 diabetes research

null

期刊论文

Copolymerization of 1-butene and 1-hexene with supported titanium catalyst

ZHAO Yongxian, SHAO Huafeng, WANG Bo, YAO Wei, HUANG Baochen

期刊论文

肿瘤光学分子影像前沿技术：追求更精准和更灵敏

王坤,迟崇巍,胡振华,刘沐寒,惠辉,尚文婷,彭冬,张爽,叶津佐,刘海哮,田捷

期刊论文

Multi-scale UDCT dictionary learning based highly undersampled MR image reconstruction using patch-based constraint splitting augmented Lagrangian shrinkage algorithm

Min YUAN,Bing-xin YANG,Yi-de MA,Jiu-wen ZHANG,Fu-xiang LU,Tong-feng ZHANG

期刊论文

Time reversal method for guided wave inspection in pipes

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